Occupational contact dermatitis due to captopril

Results We assessed a 36 years old female with a history of palpebral and lips oedema, flaking and pruritus, for two months, especially during her work. She worked in pharmaceutical industry and was referred to our outpatient because she had noticed worsening after contact with residues contained in captopril packaging during its manipulation. She had improved when had no contact with the packages. She was treated with topical corticosteroids and oral antihistamines. We performed contact delayed reading test (patch test) with captopril in the concentration of 10%, resulting papules, vesicles and swelling at the application site. In addition, there was a negative reaction standard test series. We told her to avoid new exposures to this drug and others with cross reaction.